IGF-1 LR3

Chemical Makeup:

• Molecular Weight: 9111.0 Da
• Sequence Length: 83 Amino Acids
• Molecular Formula: C400, H625, N111, O115, S9
• Synonyms: Long Arg3 IGF-1, Insulin-like Growth Factor-1 Long Arginine 3, LR3 IGF-1.
• Appearance: White to off-white lyophilized powder.
• Solubility: Soluble in water or 1% acetic acid.

[IGF-1 LR3] and Muscle Hypertrophy

Research in murine and bovine models suggests that [IGF-1 LR3] may play a critical role in the regulation of skeletal muscle mass. By binding to the IGF-1 receptor, the peptide has been observed to stimulate the proliferation and differentiation of myoblasts (muscle precursor cells). Studies indicate that activation of the PI3K/Akt/mTOR pathway promotes protein synthesis while simultaneously inhibiting protein degradation (proteolysis). Furthermore, data suggests [IGF-1 LR3] may activate satellite cells—stem cells resident in muscle tissue—facilitating myonuclear addition and potential hyperplasia (increase in cell number) under experimental conditions.

[IGF-1 LR3] and Cellular Survival (Apoptosis)

In vitro studies utilizing various cell lines have demonstrated the anti-apoptotic properties of [IGF-1 LR3]. Upon receptor activation, the peptide initiates intracellular signaling cascades that may enhance cell survival during stress conditions, such as serum deprivation. It has been observed that the phosphorylation of Akt prevents the activation of pro-apoptotic factors, thereby preserving cellular integrity. Researchers are investigating these pathways to understand the peptide's potential role in preventing cell death in degenerative tissue models.

[IGF-1 LR3] and Glucose Metabolism

While [IGF-1 LR3] shares structural homology with insulin, its metabolic effects are distinct. Animal studies have indicated that the peptide may influence nutrient partitioning—the process by which the body determines whether to store energy as fat or use it for tissue repair. Research suggests that [IGF-1 LR3] may enhance cellular glucose uptake in muscle tissue while potentially promoting the utilization of fatty acids for energy expenditure. Unlike insulin, which facilitates glucose storage primarily in adipose tissue, [IGF-1 LR3] has been observed to direct nutrients preferentially toward anabolic processes in lean tissue.

[IGF-1 LR3] and Tissue Regeneration

Investigations into wound healing and tissue repair have highlighted the potential of [IGF-1 LR3] to accelerate regenerative processes. In experimental models of tendon and ligament injury, localized administration of the peptide was associated with increased collagen synthesis and fibroblast proliferation. Studies suggest that the extended half-life of [IGF-1 LR3] allows for sustained signaling at the injury site, potentially overcoming the rapid degradation typically seen with native growth factors in inflammatory environments.

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Side Effects & Toxicity: 

In animal studies involving high-dose administration, potential adverse effects have been noted. These include transient hypoglycemia (due to insulin-receptor cross-reactivity) and organomegaly (enlargement of internal organs such as the spleen, kidneys, or intestines). Long-term exposure in varying models has raised theoretical concerns regarding unchecked cellular proliferation.

Withdrawal: 

No specific withdrawal symptoms have been documented in non-clinical literature; however, suppression of endogenous IGF-1 production via negative feedback loops is a theoretical possibility often explored in endocrine research.

WARNING: RESEARCH USE ONLY 

This product is intended exclusively for laboratory research and development purposes. It is not intended for human use, veterinary use, or therapeutic administration. It is strictly forbidden to use this product as a drug, food additive, or cosmetic agent. Any reference to biological effects is strictly based on non-clinical, academic research findings.