HCG 5000 & 10000 IU

Chemical Makeup:

• Molecular Formula: C1105, H1770, N318, O336, S26
• Molecular Weight: Approximately 36-40 kDa (Glycoprotein)
• Synonyms: Human Chorionic Gonadotropin, Choriogonadotropin, hCG3
• CAS Number: 9002-61-34

Sequence:

• Heterodimeric glycoprotein composed of an a subunit (92 amino acids) and a B subunit (145 amino acids).

The following sections summarize observed effects of HCG in varying experimental models (in vitro and in vivo). This data is for educational and research validation purposes only.

HCG and Leydig Cell Stimulation

Research utilizing murine and primate models has established HCG as a potent analogue to endogenous LH. Studies suggest that administration of HCG directly stimulates Leydig cells to upregulate the expression of steroidogenic acute regulatory protein (StAR) and other enzymes critical for the conversion of cholesterol to pregnenolone. In hypophysectomized rodent models (where pituitary LH production is ceased), HCG introduction has been observed to restore intratesticular testosterone (ITT) levels, suggesting its potential utility in maintaining Leydig cell responsiveness during periods of gonadotropin suppression.

HCG and Spermatogenesis

In clinical research involving subjects with hypogonadotropic hypogonadism, HCG has been investigated for its role in initiating or maintaining spermatogenesis. The mechanism appears to be mediated through the high intratesticular testosterone concentrations achieved via Leydig cell stimulation. It has been noted in comparative studies that while FSH is required for the full maturation of spermatozoa, HCG-mediated testosterone production provides the essential androgenic environment necessary for the progression of meiosis in germ cells.

HCG and Testicular Volume Maintenance

Experimental protocols involving exogenous androgen administration often result in the suppression of the Hypothalamic-Pituitary-Gonadal (HPG) axis, leading to testicular atrophy due to the absence of LH signaling. Research indicates that concurrent administration of HCG in these models may preserve testicular volume. It is hypothesized that by occupying LH receptors during periods of pituitary suppression, HCG prevents the cellular apoptosis and structural regression of Leydig cells typically observed in hormone-suppressed states.

HCG and Neuroprotective Signaling

Recent investigations have identified the presence of LH/CG receptors in various regions of the mammalian brain, including the hippocampus and hypothalamus. Preliminary studies in rodent models suggest that HCG may influence neurosteroidogenesis, potentially modulating synaptic density and signaling pathways related to memory and cognition. While distinct from its gonadal effects, these observations have opened new avenues of research regarding the hormone's role in neurobiology and potential neuroprotective mechanisms against excitotoxicity

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Research Use Only: 

This compound is strictly for laboratory research and development. It is not intended for human consumption, diagnostic, or therapeutic use.

In animal and clinical models, the administration of HCG has been associated with specific physiological responses and adverse events. Researchers should be aware of the following potential variables:

• Estrogenic Activity: Due to the stimulation of testosterone, secondary aromatization to estradiol has been frequently observed in research subjects.
• Desensitization: Prolonged exposure to high concentrations of HCG has been shown in vitro to potentially downregulate LH/CG receptor density on Leydig cells, leading to temporary insensitivity (Leydig cell desensitization).
• Injection Site Reactions: Localized irritation or inflammation has been noted in subcutaneous administration protocols.

Handling Instructions: 

This product is supplied as a lyophilized powder. It must be reconstituted with bacteriostatic water or a sterile saline solution. Once reconstituted, the solution should be stored at 4°C and used within the timeframe specified by standard laboratory protocols for peptide stability (typically 14-30 days)