HGH 191AA

Chemical Makeup:

• Molecular Formula: C990, H1529, N263, O299, S7
• Molecular Weight: 22,125 Da (22 kDa)
• Synonyms: Somatropin, Recombinant Human Growth Hormone, rHGH, GH.

Sequence:

• 191 Amino Acid Recombinant Protein

[HGH 191AA] and Skeletal Muscle Hypertrophy

Research indicates that [HGH 191AA] may influence skeletal muscle anabolism primarily through the IGF-1 axis. In murine and human models, the administration of Somatropin has been observed to increase nitrogen retention and stimulate protein synthesis. The mechanism appears to involve the proliferation of myoblasts and the differentiation of satellite cells, which are precursors to muscle cells. Studies suggest that while [HGH 191AA] alone may not drastically increase contractile protein accretion in healthy subjects, it plays a critical role in preventing catabolism (muscle breakdown) under varying physiological stressors.

[HGH 191AA] and Lipid Metabolism (Lipolysis)

Distinct from its anabolic effects, [HGH 191AA] has been shown to possess direct lipolytic properties. Receptors for growth hormone are abundant in adipose tissue. In vitro studies demonstrate that [HGH 191AA] stimulates the hydrolysis of triglycerides into free fatty acids (FFAs) and glycerol. Furthermore, it has been observed to inhibit lipoprotein lipase (LPL) activity, the enzyme responsible for accumulating lipids in fat cells. This dual mechanism suggests a potential shift in energy metabolism toward fatty acid oxidation.

[HGH 191AA] and Bone Mineral Density

Longitudinal studies in adult subjects with growth hormone deficiencies suggest that [HGH 191AA] is vital for bone remodeling. The peptide stimulates osteoblast proliferation and activity, leading to increased bone formation. It has been observed that during the initial phases of research administration, bone resorption markers may increase, followed by a sustained period of bone formation and mineralization. Data indicates that prolonged exposure to physiological levels of recombinant GH correlates with improved lumbar and femoral neck bone mineral density (BMD).

[HGH 191AA] and Connective Tissue Synthesis

Research highlights the role of the GH/IGF-1 axis in the synthesis of collagen, the primary structural protein in skin, tendons, and ligaments. In fibroblast cultures, [HGH 191AA] has been shown to upregulate collagen type I and type III expression. Clinical observations in wound healing models suggest that systemic administration may accelerate the tensile strength recovery of incised wounds, potentially by enhancing the deposition of collagen matrix and increasing the cellularity of the wound bed.

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Side Effects: 

In animal and human trials, several physiological side effects have been documented, particularly at supraphysiological dosages. Common observations include fluid retention (peripheral edema) and arthralgia (joint pain), likely resulting from sodium and water retention. Carpal tunnel syndrome has been reported in subjects due to fluid compression of the median nerve. Additionally, [HGH 191AA] can induce insulin resistance; it antagonizes the action of insulin, potentially leading to elevated fasting blood glucose levels and glucose intolerance in susceptible models.

Research Use Only: 

This product is sold for laboratory research use only. It is not intended for human consumption, diagnostic, or therapeutic use. All information presented is for educational purposes based on academic literature.